Clinical Microbiology as a branch of science deals with the interrelation of macro- and microorganisms under normal and pathological conditions. It provides comprehensive information on the identification of different microorganisms and outlines recent vicissitudes in taxonomy. Microbial profiling is the relegation of microbes predicated on experiments, resulting expeditious identification. This system is developed for expeditious identification of clinically germane organisms and hence only kenned microbes can be identified. The predominant proteomic technologies that have been explored for microbial identification and characterization include matrix-availed laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS); electro spray ionization mass spectrometry (ESI-MS); surface-enhanced laser desorption/ionization (SELDI) mass spectrometry; one- or two-dimensional sodium dodecyl sulphate–polyacrylamide gel electrophoresis (SDS-PAGE); or the coalescence of MS, gel electrophoresis and bioinformatics. In the context of plants, two symbiotic systems have been actively studied for many years. One is arbuscular mycorrhizal (AM) symbiosis and the other is root nodule (RN) symbiosis. Oral bacteria have evolved mechanisms to sense their environment and eschew or modify the host.